Eileen M Shore Selected Research

Inborn Genetic Diseases (Disease, Hereditary)

1/2022	BMP signaling and skeletal development in fibrodysplasia ossificans progressiva (FOP).
1/2021	Dysregulated BMP signaling through ACVR1 impairs digit joint development in fibrodysplasia ossificans progressiva (FOP).
1/2019	ACVR1R206H FOP mutation alters mechanosensing and tissue stiffness during heterotopic ossification.
1/2018	Depletion of Mast Cells and Macrophages Impairs Heterotopic Ossification in an Acvr1R206H Mouse Model of Fibrodysplasia Ossificans Progressiva.
7/2017	The congenital great toe malformation of fibrodysplasia ossificans progressiva? - A close call.
11/2016	ACVR1-Fc suppresses BMP signaling and chondro-osseous differentiation in an in vitro model of Fibrodysplasia ossificans progressiva.
12/2012	CNS demyelination in fibrodysplasia ossificans progressiva.
1/2012	Functional analysis of alleged NOGGIN mutation G92E disproves its pathogenic relevance.
11/2011	Heterozygous inactivation of Gnas in adipose-derived mesenchymal progenitor cells enhances osteoblast differentiation and promotes heterotopic ossification.
11/2011	Fibrodysplasia ossificans progressiva: a blueprint for metamorphosis.

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Eileen M Shore Research Topics

Disease

42	Myositis Ossificans (Fibrodysplasia Ossificans Progressiva) 01/2022 - 01/2003
18	Heterotopic Ossification (Ectopic Ossification) 01/2019 - 09/2003
16	Inborn Genetic Diseases (Disease, Hereditary) 01/2022 - 04/2003
5	Inflammation (Inflammations) 01/2016 - 01/2003
3	Mucopolysaccharidoses 01/2022 - 11/2015
3	Mucopolysaccharidosis I (Hurler Syndrome) 01/2022 - 07/2013
3	Pseudohypoparathyroidism 01/2020 - 05/2007
3	Progressive Osseous Heteroplasia 01/2018 - 04/2003
2	Lysosomal Storage Diseases (Lysosomal Storage Disease) 01/2022 - 12/2014
2	Bone Diseases (Bone Disease) 01/2022 - 11/2019
2	Type 2 Diabetes Mellitus (MODY) 01/2020 - 01/2018
2	Obesity 01/2020 - 01/2018
2	Brachydactyly 01/2020 - 07/2017
2	Hypogonadism (Hypergonadotropic Hypogonadism) 01/2020 - 01/2018
2	Disease Progression 12/2014 - 02/2007
1	Diffuse Intrinsic Pontine Glioma 01/2021
1	Osteochondrodysplasias (Spondyloepiphyseal Dysplasia) 11/2020
1	Hypothyroidism 01/2020
1	Hypertension (High Blood Pressure) 01/2018
1	Weight Gain 01/2018
1	Glucose Intolerance 01/2018
1	Congenital Abnormalities (Deformity) 01/2018
1	Hallux Valgus 07/2017
1	Hypertrophy 11/2015
1	Type B1 Brachydactyly 01/2012
1	Edema (Dropsy) 12/2011
1	Fatigue 12/2011
1	Virus Diseases (Viral Diseases) 12/2011
1	Soft Tissue Injuries (Soft Tissue Injury) 12/2011
1	Neoplasms (Cancer) 02/2008
1	Osteochondroma (Osteocartilaginous Exostosis) 02/2008
1	Aplastic Anemia (Anemia, Hypoplastic) 02/2007
1	Paresis (Hemiparesis) 04/2003

Drug/Important Bio-Agent (IBA)

28	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 01/2022 - 04/2003
13	Type I Bone Morphogenetic Protein ReceptorsIBA 11/2020 - 05/2006
7	Activin Receptors (Activin Receptor)IBA 11/2020 - 01/2008
6	Bone Morphogenetic Protein ReceptorsIBA 01/2021 - 05/2014
5	GlycosaminoglycansIBA 01/2022 - 07/2013
5	Serine (L-Serine)FDA Link 06/2012 - 09/2007
5	Glycine (Aminoacetic Acid)FDA LinkGeneric 06/2012 - 09/2007
4	activin AIBA 01/2018 - 02/2008
4	Phosphotransferases (Kinase)IBA 07/2017 - 03/2009
4	Activins (Activin)IBA 07/2017 - 05/2007
4	Proteins (Proteins, Gene)FDA Link 09/2007 - 03/2003
3	Iduronidase (alpha-L-Iduronidase)IBA 01/2022 - 07/2013
3	GTP-Binding Proteins (G-Protein)IBA 11/2011 - 04/2003
3	Adenylyl Cyclases (Adenylyl Cyclase)IBA 11/2011 - 04/2003
2	Codon (Codons)IBA 01/2022 - 05/2008
2	Parathyroid Hormone (Parathormone)IBA 01/2020 - 01/2018
2	Growth Hormone (Somatotropin)IBA 01/2020 - 01/2018
2	GlucuronidaseIBA 11/2019 - 11/2015
2	PalovaroteneIBA 01/2019 - 01/2016
2	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 04/2003
2	LigandsIBA 01/2018 - 09/2007
2	Messenger RNA (mRNA)IBA 11/2015 - 04/2003
2	Bone Morphogenetic Protein 4IBA 04/2007 - 03/2004
2	RNA (Ribonucleic Acid)IBA 04/2003 - 03/2003
1	EnzymesIBA 01/2022
1	LithiumIBA 01/2022
1	Dermatan SulfateIBA 01/2022
1	dipinacoline glutamateIBA 01/2021
1	Chondroitin Sulfates (Chondroitin Sulfate)IBA 11/2019
1	Biomarkers (Surrogate Marker)IBA 11/2019
1	Oxygen (Dioxygen)IBA 01/2016
1	Differentiation AntigensIBA 11/2015
1	Simvastatin (Zocor)FDA LinkGeneric 12/2014
1	Heparitin Sulfate (Heparan Sulfate)IBA 07/2013
1	Amino Acids FDA Link 01/2012
1	Adrenal Cortex Hormones (Corticosteroids)IBA 12/2011
1	Substance PIBA 10/2011
1	Pharmaceutical PreparationsIBA 10/2009
1	Collagen Type I (Type I Collagen)IBA 09/2009
1	matrigelIBA 03/2009
1	CardiotoxinsIBA 03/2009
1	NucleotidesIBA 05/2008
1	Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)IBA 12/2007
1	Lysine (L-Lysine)FDA Link 09/2007
1	Histidine (L-Histidine)FDA Link 09/2007
1	Aspartic Acid (Aspartate)FDA Link 09/2007
1	SaltsIBA 09/2007
1	Hormones (Hormone)IBA 05/2007
1	Explosive Agents (Explosives)IBA 09/2003
1	Transcription Factors (Transcription Factor)IBA 09/2003
1	chordinIBA 04/2003
1	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 04/2003
1	FollistatinIBA 04/2003
1	NF-kappa B (NF-kB)IBA 01/2003

Therapy/Procedure

5	Therapeutics 01/2022 - 05/2007
2	Intramuscular Injections 12/2011 - 03/2009
1	Enzyme Replacement Therapy 12/2014
1	Transplantation 02/2007
1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 02/2007